Brief Report
Towards an improved AIDS vaccine: Enhancing the MHC Class I and II Antigen presentation of SIV proteins using ubiquitin and HLA-Dm targeting sequences
Published 2020-12-01
Keywords
- HIV,
- AIDS,
- vaccine
How to Cite
1.
Martinu T, Hel Z, Franchini G. Towards an improved AIDS vaccine: Enhancing the MHC Class I and II Antigen presentation of SIV proteins using ubiquitin and HLA-Dm targeting sequences. McGill J Med [Internet]. 2020 Dec. 1 [cited 2025 Oct. 5];6(1). Available from: https://mjm.mcgill.ca/article/view/528
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
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References
- `1. Luciw PA. Human immunodeficiency viruses and their replication. In: Fields BN, Knipe DM, Howley PM, eds. Fields Virology. Philadelphia: Lippincott-Raven Publishers; 1996.
- Benson J, Chougnet C, Robert-Guroff M, et al. Recombinant vaccine-induced protection against the highly pathogenic simian immunodeficiency virus SIVmac251: dependence on route of challenge exposure. Journal of Virology 1998; 72: 4170-4182.
- Schneider J, Gilbert SC, Blanchard TJ, et al. Enhanced immunogenicity for CD8+ T cell induction and complete protective efficacy of malaria DNA vaccination by boosting with modified vaccinia virus Ankara. Nature Medicine 1998; 4: 387-402.
- Michalek MT, Grant EP, Gramm C, et al. A role for the ubiquitin-dependent proteolytic pathway in MHC class I- restricted antigen presentation. Nature 1993; 363: 552-554.
- Rodriguez F, Zhang J, Whitton JL. DNA immunization: ubiquitination of a viral protein enhances cytotoxic T- lymphocyte induction and antiviral protection but abrogates antibody induction. Journal of Virology 1997; 71: 8497-8503.
- Kelly AP, Monaco JJ, Cho S, Trowsdale J. A new human HLA class II-related locus, DM. Nature 1991; 353: 571-573.
- Lindsted R, Liljedahl M, Peleraux A, et al. The MHC class II molecule H2-M is targeted to an endosomal compartment by a tyrosine-based targeting motif. Immunity 1995; 3: 561-572.
- Marks MS, Roche PA, van Donselaar E, et al. (1995) A lysosomal targeting signal in the cytoplasmic tail of the b chain directs HLA-DM to MHC class II compartments. Journal of Cell Biology 1995 131: 351-369.
- Wu T-C, Guarnieri FG, Staveley-O’Carroll KF, et al. Engineering an intracellular pathway for major histocompatibility complex II presentation of antigens. Immunology 1995; 92: 11671-11675.
- Baker RT, Board PG. The human ubiquitin gene family: structure of a gene and pseudogenes from the Ub B subfamily. Nucleic Acids Research, 1987; 15: 443-463.
- Ausbel FM, et al., eds. Current Protocols in Molecular Biology. New York: Greene Publishing Associates and Wiley- Interscience; 1987 (updated bimonthly).