Vol. 11 No. 2 (2008)
A Case Of Atypical Gastric Carcinoma With Osteoclast Like Giant Cells
- Rahul Pandit
- Irina A. Danilova
Out of all the different types of neoplasms affecting the stomach, gastric carcinomas with Osteoclast-like Giant Cells (OGC) is one of the most uncommon. Although OGC are typically found in osseous neoplasms and tumors of the tendon sheath, few cases of extra-skeletal neoplasms with OGC have been documented. These typically involve organs such as the pancreas, gall-bladder, kidney, and breast. Even though the role of OGC in histogenesis of such tumors still remains unclear, their presence in extra-osseous neoplasms may indicate a certain level of immune reaction of the host towards the neoplastic transformation of normal tissue. We report a case of a 70-year-old Caucasian female hospitalized for evaluation of epigastric pain. Further examinations including endoscopy and biopsy of the stomach revealed gastric adenocarcinoma with OGC. This report also provides a brief insight into the possible immune reaction in such neoplasms
- Young-E J et all -A Case of Osteoclast-like Giant Cell Tumor of the Pancreas with Ductal Adenocarcinoma: Histopathological, Immunohistochemical, Ultrastructural andMolecular Biological Studies-J Korean Med Sci 2005; 20: 516-20 ISSN 1011-8934
- Shoichi D et all - Undifferentiated Spindle and Giant Cell Carcinoma of the Common Bile Duct- Tokai J Exp Clin Med., Vol. 28, No. 3, pp. 127-130, 2003
- Baschinsky DY, Frankel WL, Niemann TH-Gastric carcinoma with osteoclast-like giant cells-Am J Gastroenterol. 1999 Jun; 94(6):1678-81
- Stracca-Pansa V et all- Gastric carcinoma with osteoclast-like giant cells : report of four cases- Am So of Cl Patholo and the College of Am Patholo. Spring meeting, Orlando FL , (22/04/1995) 1995, vol. 103, no 4, pp. 500-528
- Mayer, E. K , Beckley I. and Winkler M.H,- Lymphoepithelioma-like carcinoma of the urinary bladder— diagnostic and clinical implications- Nature clinical practice urology (2007) 4 pp 197-171
- Torlakovic G, Snover D. C., and Torlakovic E. -Simultaneous EBV-Positive Lymphoepithelioma-like Carcinoma and EBVNegative Intestinal Type Adenocarcinoma in a Patient With Helicobacter pylori–Associated Chronic Gastritis- Am J Clin Pathol 2004
- Shibata D, Tokunaga M, Uemura Y, Sato E, Tanaka S andWeiss L M- Association of Epstein-Barr virus with undifferentiated gastric carcinomas with intense lymphoid infiltration. Am J of Pathol, Vol 139, 469-474
- Müller W, Schneiders A, Hommel G, Gabbert HE.-Prognostic value of BCL2 in gastric cancer-Anticancer research 1998 Nov - Dec;18(6B):4699-704.
- Zafirellis K, Karameris A, Milingos N, Androulakis G.- Molecular markers in gastric cancer: can p53 and bcl-2 protein expressions be used as prognostic factors? Anticancer Research 2005 Sep-Oct;25(5):3629-36.
- Forones NM, Carvalho AP, Giannotti-Filho O, Lourenço LG, Oshima CT.- Cell proliferation and apoptosis in gastric cancer and intestinal metaplasia.- Arq Gastroenterol. 2005 Jan-Mar;42(1):30-4. Epub 2005 Jun 22
- Ishii H, Gobé G, Kawakubo Y, Sato Y, Ebihara Y.- Interrelationship between Epstein-Barr virus infection in gastric carcinomas and the expression of apoptosis-associated proteins.- Histopathology. 2001 Feb;38(2):111-9
- Chang MS, Lee HS, Jung EJ, Kim CW, Lee BL, KimWH.- Role and prognostic significance of proapoptotic proteins in Epstein-Barr virus-infected gastric carcinomas-Anticancer Research 2007 Mar-Apr;27(2):785-9
- Kume T, Oshima K, Shinohara T, Takeo H, Yamashita Y, Shirakusa T, Kikuchi M.- Low rate of apoptosis and overexpression of bcl-2 in Epstein-Barr virus-associated gastric carcinoma.-Histopathology-1999 Jun;34(6):502-9
Download data is not yet available.