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An Approach To:

Vol. 1 No. 1 (1995)

Retinopathy of Prematurity: A Clinical Approach

DOI
https://doi.org/10.26443/mjm.v1i1.435
Submitted
October 31, 2020
Published
2020-12-01

Abstract

Retinopathy of prematurity (ROP), previously known as retrolental fibroplasia, was first described by Terry in 1942 (1). It is a vasoproliferative disorder that is a leading cause of childhood blindness in the United States, causing 550 new cases of infant blindness each year (2). It occurs principally in premature infants treated with high concentrations of oxygen. There are two phases of ROP: (i) an acute phase in which normal vasculogenesis is interrupted, and (ii) a chronic phase in which vascular membranes proliferate into the
vitreous. This proliferation can lead to retinal detachment, scarring of the macula, and significant visual loss (3).
This article summarizes the incidence, pathophysiology, and classification of ROP. Current protocols for evaluating and treating ROP, as well as long-term sequelae, are also described.

References

  1. Terry TL. Extreme prematurity and fibroplastic overgrowth of persistent vascular sheath behind each crystalline lens. American Journal of Ophthalmology 1942:25:203-204.
  2. Vaughan D, Asbury T, Riordan-Eva P. General Ophthalmology. Connecticut: Appleton and Lange, 1993:201.
  3. Taylor D, et al. Pediatric Ophthalmology. Boston: Blackwell Scientific Publication, 1990:371-372.
  4. Kaline RE. Retrolental fibroplasia - experience over two decades in one institution. Ophthalmology 1982;89:91-95.
  5. Tasman W. The natural history of active retinopathy of prematurity. Ophthalmology 1984;91:1499-1502.
  6. Palmer EA, Flynn JT, Hardy RJ, et al. Incidence and early course of retinopathy of prematurity. Ophthalmology 1991;98:1628-1640.
  7. Flynn JT. Retinopathy of prematurity. Pediatric Clinics of North America 1987;34:1487-1516.
  8. Weakley DR, Spencer R. Current concepts in retinopathy of prematurity. Early Human Development 1992;30:121-138.
  9. The Committee for the Classification of Retinopathy of Prematurity. An international classification of Retinopathy of Prematurity. Archives of Ophthalmology 1984;102:1130-1134.
  10. The International Committee for the Classification of the Late Stages of Retinopathy of Prematurity. An international classification of retinopathy of prematurity. Archives of Ophthalmology 1987;105:906-912.
  11. American Academy of Pediatrics and American College of Obstetricians and Gynecologists. Guidelines for Perinatal Care, 3rd ed., Washington, DC, 1992.
  12. Palmer EA. Optimal timing of examination for acute retrolental fibroplasia. Ophthalmology 1981;88:662- 668.
  13. Taylor D, et al. Pediatric Ophthalmology. Boston: Blackwell Scientific Publication, Boston, 1990:372- 373.
  14. Quinn GE, Johnson L, Otis CH, et al. Incidence, severity and time course of ROP in a randomized clinical trial of vitamin E prophylaxis. Documenta Ophthalmologica 1990;74:223-228.
  15. Phelps DL, Rosenbaum AL, Isenberg SL, et al. Tocopherol efficacy and safety for preventing retinopathy of prematurity: a randomized, controlled, double-masked trial. Pediatrics 1987;79:489-500.
  16. Schaffer DB, Johnson L, Quinn GE, et al. Vitamin E and retinopathy of prematurity. Follow up at 1 year. Ophthalmology 1985;92:1005-1011.
  17. Johnson L, Bowen F, Hermann N. The relationship of prolonged elevation of serum vitamin E levels to neonatal bacterial sepsis and necrotizing enterocolitis. Pediatric Research 1983;17:319A.
  18. Johnson L, Quinn GE, Abbasi S, et al. Effect of sustained vitamin E levels on incidence and severity of retinopathy of prematurity: a controlled clinical trial. Journal of Pediatrics 1989;114:827-838.
  19. Finer NN, Schindler RF, Grant G, et al. Effect of intramuscular vitamin E on frequency and severity of retrolental fibroplasia. A controlled trial. Lancet 1982;1:1087-1091.
  20. Pucklin JE, Simon RM, Ehrenkranz RA. Influence on retrolental fibroplasia of intramuscular vitamin E administration during respiratory distress syndrome. Ophthalmology 1982;89:96-103.
  21. Ben Sira I, Nissenkorn I, Kremer I. Retinopathy of Prematurity. Survey of Ophthalmology 1988;33(1):1- 16.
  22. Cryotherapy for Retinopathy of Prematurity Cooperative Group. Multicenter trial of cryotherapy for retinopathy of prematurity. 3-month outcome. Cryotherapy for retinopathy of prematurity. Archives of Ophthalmology 1990;108:195-204.
  23. Cryotherapy for Retinopathy of Prematurity Cooperative Group. Multicenter trial of cryotherapy for retinopathy of prematurity: 1-year outcome. Structure and function. Archives of Ophthalmology 1990;108:1408-1416.
  24. McNamara JA, Tasman W, Brown GC, et al. Laser photocoagulation for stage 3+ retinopathy of prematurity. Ophthalmology 1991;98:576-580.
  25. Phelps DL. Retinopathy of prematurity. Pediatric Clinics of North America 1993;40(4):705-714.
  26. Flynn JT, Tasman W. Retinopathy of Prematurity - A clinician's guide. New York: Springer-Verlag, New York, 1992:63-71.
  27. Quinn GE, Dobson V, Barr CH, et al. Visual acuity in infants after vitrectomy for severe retinopathy of prematurity. Ophthalmology 1991;98:5-13.
  28. Trese MT. Surgical results of stage V retrolental fibroplasia and timing of surgical repair. Ophthalmology 1984;91:461-466.
  29. Tasman W, Borrone RN, Bolling J. Open sky vitrectomy for total retinal detachment in retinopathy of prematurity. Ophthalmology 1987;94:449-452.
  30. Albert DM, Jakobiec FA. Principles and practice of ophthalmology. Philadelphia: WB Saunder Co. Philadelphia, 1994:2809-2812.
  31. Biglan AW, Cheng KP, Brown DR. Update on ROP. International Ophthalmology Clinics 1989;29:2-9.
  32. Cats BP, Tan K. Premature with and without regressed ROP: comparison of long-term ophthalmological morbidity. Journal of Pediatric Ophthalmology 1989;26:271-275.
  33. Snir M, Nissenkorn I, Sherf I, et al. Visual acuity, strabismus, amblyopia in premature babies with and without ROP. Annals of Ophthalmology 1988;20:256-258.
  34. Kitchen WH, Yu VY, Orgill A, et al. Collaborative study of very low birth weight infants: outcome of 2- year-old survivors. Lancet 1982;1:1457-1460.
  35. Tasman W. Late complications of retrolental fibroplasia. Ophthalmology 1979;86:1724-1740.

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