Skip to main navigation menu Skip to main content Skip to site footer
##common.pageHeaderLogo.altText##

Research Article

Vol. 6 No. 2 (2002)

Molecular Cloning and Expression of Human Regulators of G-Protein Signaling 4, 5, and 16

  • Aravind Athiviraham
DOI
https://doi.org/10.26443/mjm.v6i2.776
Submitted
November 19, 2020
Published
2020-12-01

Abstract

N/A

References

  1. De Vries, L., Zheng, B., Fischer, T., Elenko, E., and Farquhar, M. (2000) The Regulator of G-protein signalling family. Annu. Rev. Pharmacol. Toxicol. 40, 235-271
  2. Panetta, R., Guo, Y., Magder, S. and Greenwood, M. T. (1999) Regulators of G-protein signalling (RGS) 1 and 16 are induced in response to bacterial lipopolysacchiride and stimulate c-fos promoter expression. Biochem. Biophys. Res. Commun. 259, 550-556
  3. Grant, S. L., Lassegue, B., Griendling, K. K., Fukai, M. U., Lyons, P. R. and Alexander, R. W. (2000) Specific regulation of RGS2 messenger RNA by Angiotensin II in cultured vascular smooth muscle cells. Molec. Pharmacology, 57, 460-467.
  4. Fong, C. W., Zhang, Y., Neo, S. Y., and Lin, S. C. (2000) Specific induction of RGS16 mRNA by protein kinase C in CEM leukaemia cells is mediated via tumour necrosis factor a in a calcium-sensitive manner. Biochem. J., 352, 747-753
  5. Chen, C., Zheng, B., Han, J., and Lin, S.-C. (1997) Characterization of a novel mammalian RGS protein that binds to Ga proteins and inhibits pheromone signalling in yeast. J. Biol. Chem. 272, 8679-8885
  6. Tamirisa, P., Blumer, K. J., Muslin, A. J. (1998) RGS4 Inhibits G-protein Signaling in Cardiomyocytes. Circulation, 99, 441-447
  7. Limbird, L. E., and Vaughan, D. E. (1999) Augmenting b receptors in the heart: Short-term gains offset by long term pains? Proc. Natl. Acad. Sci. 96, 7125-7127
  8. Zhang, S., Watson, N., Zahner, J., Rottman, J. N., Blumer, K. J., and Muslin, A. J. (1998) RGS3 and RGS4 are G-protein inhibitors in the heart. J. Mol. Cell Cardiol. 30, 269-276
  9. Owen, V. J., Burton, B. J., Mullen, A. J., Birks, E. J., Barton, P., and Yacoub, M. H., (2001) Expression of RGS3, RGS4 and Gi alpha 2 in acutely failing donor hearts and end-stage heart failure. European Heart Journal, 22, 1025-1020
  10. Kong, Janice (2001) Master of Science (MSc) Thesis, McGill University.
  11. Rogers, J. H., Tsirka, A., Kovacs, A., Blumer, J. K., Dorn, G. W., Muslin, A. J. (2001) RGS4 reduces contractile dysfunction and hypertrophic gene induction in Gaq overexpressing mice. J. Mol. Cell Cardiol. 33, 209-218
  12. http://www.ncbi.nlm.nih.gov/Genbank/index.html
  13. Greenwood M.T., Hukovic, N., Kumar, U., Panetta, R., Hjorth, S.A., Srikant, C.B., Patel, Y.C. (`997) Ligand binding pocket of the human somatostatin receptor 5: mutational analysis of the extracellular domains. Mol. Pharmacol. 52, 807-814
  14. Greenwood, M.T., Guo, Y., Kumar, U., Beausejours, S., Hussain, S.N. (1997) Distribution of protein inhibitor of neuronal nitric oxide synthase in rat brain. Biochem. Biophys. Res. Commun. 238, 617-621
  15. Mumberg, D., Muller, R., and Funk, M. (1994) Regulatable promoters of Saccharomyces cerevisiae: comparison of transcriptional activity and their use for heterologous expression. Nucleic Acids Res. 22, 5767-5768
  16. Dohlman, H. G., Song, J., Ma, D., Courchesne, W. E., and Thorner, J. (1996) SSt2, a Negative regulator of pheromone signalling in the yeast Saccharomyces cerevisiae: expression, localization, and genetic interaction and physical association with Gpa1 (the G-protein a subunit) Mol. Cell. Biol. 16, 5194- 5209
  17. Gietz, D., St Jean, A., Woods, R. A. , Schiestl, R. H. (1992) Improved method for high efficiency transformation of intact yeast cells. Nucleic Acids Res. 20, 1425
  18. Druey, K. M., Blumer, K. J., Kang, V. H., Kehrl, J. H. (1996) Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family. Nature. 379, 742-746

Downloads

Download data is not yet available.