Spectral Differences Between Normal and Atherosclerotic Aorta
Ischemic heart disease associated with coronary artery atherosclerosis is a leading cause of
death in the world today. In addition to standard treatments such as balloon angioplasty, laser mediated angioplasty is being considered as a potential adjuvant or replacement. Nevertheless, experiments and clinical experience have demonstrated that laser angioplasty is associated with damage to normal vessel tissue, which can cause serious complications. To study the possibility of minimizing these effects by directing laser energy more specifically to atherosclerotic lesions, data concerning the spectral characteristics of normal and diseased artery are necessary. In the current study, the absorbance, reflection and fluorescence spectra of normal and atherosclerotic aortic wall tissue are defined, revealing that (i) spectral characteristics of atherosclerotic aorta wall samples are significantly differed from that of healthy vascular wall samples and (ii) based on a spectral analysis of vascular wall, it is possible to distinguish morphological types of atherosclerotic plaques (i.e., lipidic, calcified). The current study contributes to a more complete understanding of laser-tissue interactions that may, following more experimentation and technique development, result in an improvement of clinical laser angioplasty technique.
- Libby P. Atherosclerosis. In: Fauci AS et al., eds. Harrison's Principles of Internal Medicine, 14th Edition. New York: McGraw-Hill; 1998; 1345-1352.
- Sanborn TA. Laser angioplasty: peripheral and coronary applications. Cardiovascular Clinics. 19:181-95; 1988.
- Wollenek G, Laufer G, and Haschkovitz H. Koronare laserantioplastie. Herz 10: 351-356; 1985.
- Abela GS, Suger JM, Barbieri E, et al. Laser angioplasty with angioscopic guidance in humans. Journal of the American College of Cardiology 8: 184-192; 1986.
- Litvack F, Grundfest WS, Segalowiatz J, et al. Interventional cardiovascular therapy by laser and thermal angioplasty. Circulation. 81 (Supplement 4):109-116; 1990.
- Abela GS, Normann S, Cohen D, et al. Effects of carbon dioxide, Nd-YAG and argon laser radiation or coronary atheromatous plaques. American Journal of Cardiology 50: 1199-1205; 1982.
- Ginsburg R, Kim DS, Guthaner D, et al. Salvage of an ischemic limb by laser angioplasty: description of a new technique. Clinical Cardiology 7: 54-8; 1984.
- Geschwind H, Boussignac G, Teisseire B, et al. Percutaneous transluminal laser angioplasty in man. Lancet. 1(8381): 844; 1984
- Isner JM, Rosenfield K, White CJ, et al. In vivo assessment of vascular pathology resulting from laser irradiation. Analysis of 23 patients studied by directional atherectomy immediately after laser angioplasty. Circulation 85: 2185-2196; 1992.
- Litvack F, Eigler NL and Forrester JS. Excimer laser coronary angioplasty. Science and Medicine 3(1): 42-51; 1996.
- Grundfest WS, Litvack F, Forrester JS, et al. Laser ablation of human atherosclerotic plaque without adjacent tissue injury. Journal of the American College of Cardiology 5:929-933; 1985.
- Isner JM, Donaldson RF, Deckelbaum LI, et al. The excimer laser: gross, light microscopic and ultrastructural analysis of potential advantages for use in laser therapy of cardiovascular
- disease. Journal of the American College of Cardiology 6:1102-1109; 1985.
- Sartori M, Henry PD, Sauerbrey R, et al. Tissue interactions and measurement of ablation rates with ultraviolet and visible lasers in canine and human arteries. Lasers in Surgery and Medicine 7:300-306; 1987.
- Bittl JA. Excimer laser coronary angioplasty: relative risk analysis of acute and follow-up results in 200 patients. Circulation 86: 71-80; 1992.
- Bittl JA, Sanborn TA, Tcheng JE, et al. Clinical success, complications and restenosis rates with excimer laser coronary angioplasty, the percutaneous excimer laser coronary angioplasty registry. American Journal of Cardiology 70:1533-1539; 1992.
- Margolis JR, Metha SM. Excimer laser coronary angioplasty. American Journal of Cardiology 69: 3-11F; 1992.
- Cook SL, Eigler NL, Shefer A, et al. Percutaneous excimer laser coronary angioplasty of lesions not ideal for balloon angioplasty. Circulation 84:632-643; 1991.
- Bittl JA, Sanborn TA. Excimer laser-facilitated coronary angioplasty. Relative risk analysis of acute and follow-up results in 200 patients. Circulation 86:71-80; 1992.
- Holmes DR, Vliestra RE, Smith HC, et al. Chronic total obstruction and short-term outcome: the excimer laser coronary angioplasty registry experience. Mayo Clinics Proceedings 68:
- -10; 1993.
- Lee G. Eximer laser coronary angioplasty: it's time for a critical evaluation. American Journal of Cardiology 69:1640-1643; 1992.
- Margolis JR, Litvack F, Krauthamer D, et al. Coronary angioplasty with laser and high frequency energy. eximer laser coronary angioplasty: American multicenter experience. Herz
- : 223-232; 1990.
- Bittl JA. Clinical results with excimer laser coronary angioplasty. Seminars in Interventional Cardiology 1: 129-134; 1996.
- Holmes DR Jr, Mehta S, George CJ, et al. Excimer laser coronary angioplasty: the new approaches to coronary intervention (NACI) experience. American Journal of Cardiology 80: 99K-105K.
- Strikwerda S, Koolen JJ, de Feyter PJ, et al. Excimer laser coronary angioplasty in the Netherlands: preamble for a randomized study. American Heart Journal 125: 838-847; 1993.
- Appelman YEA, Piek JJ, Strikwerda S, et al. Randomised trial of excimer laser angioplasty versus balloon angioplasty for treatment of obstructive coronary artery disease. Lancet 347:79-84; 1996.
- Appelman, YEA; Piek, JJ; Redekop, WK, et al. Clinical events following excimer laser angioplasty or balloon angioplasty for complex coronary lesions: subanalysis of a randomised trial. Heart 79: 34-38; 1998.
- van Leeuwen TG, Velema E, Pasterkamp G et al. Saline flush during excimer laser angioplasty: short and long term effects in the rabbit femoral artery. Lasers in Surgery and Medicine 23: 128-140; 1998.
- Hasse KK, Rose C, Duda S et al. Perspective of coronary excimer laser angioplasty: multiplexing, saline flushing and acoustic ablation controls. Lasers in Surgery and Medicine 21: 72-78; 1997.
- Leon MB, Lu DY, Prevosti LG, et al. Human arterial surface fluorescence: atherosclerotic plaque identification and effects of laser atheroma ablation. Journal of the American College of Cardiology 12: 94-102; 1988.
- Arakawa K, Papazoglou T, Papaioannou T, et al. XeCl excimer laser-induced fluorescence for selective ablation of atheromatous tissue. Japanese Circulation Journal 55: 1094-1095; 1991.
- Cutruzzola FW, Stetz ML, O'Brien KM, et al. Change in laser- induced arterial fluorescence during ablation of atherosclerotic plaque. Lasers in Surgery and Medicine 9:109-116; 1989.
- Morguet AJ, Korber B, Abel B, et al. Autofluorescence spectroscopy using a XeCl excimer laser system for simultaneous plaque ablation and fluorescence excitation. Lasers in Surgery and Medicine 14: 238-248; 1994.
- Deckelbaum LI, Lam JK, Cabin HS, et al. Discrimination of normal and atherosclerotic aorta by laser-induced fluorescence. Lasers in Surgery and Medicine 7:330-335; 1987.
- Kats VA, Vorob'ev SV, Stebakova LN, et al. Aspects of morphology of photodynamic destruction. Arkhiv Patologi (Moskva) 58: 1-68; 1996.
Download data is not yet available.