Trauma and Injury Severity Score (TRISS) has been the benchmark of mortality risk
in trauma centers for over 30 years. TRISS utilizes the Injury Severity Score (ISS) as an index of
anatomical injury. This study investigated the efficacy of a new type of index of anatomical injury called the ICD-derived Injury Severity Score (ICISS) compared to the ISS using a logistic
regression analysis and a global chi-square test of the areas under the Receiver Operator
Characteristic (ROC) curves. We found that the empirically derived ICISS performed as well as the consensus derived ISS with no statistical differences between their respective area under the ROC curves.