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Narrative Review

Vol. 11 No. 1 (2008)

The significance of nanoparticles in particle- induced pulmonary fibrosis

  • James Byrne
  • John A Baugh
DOI
https://doi.org/10.26443/mjm.v11i1.455
Submitted
November 1, 2020
Published
2020-12-01

Abstract

Exposure to airborne nanoparticles contributes to many chronic pulmonary diseases. Nanoparticles, classified as anthropogenic and natural particles, and fibers of diameters less than 100 nm, have unrestricted access to most areas of the lung due to their size. Size relates to the deposition efficiency of the particle, with particles in the nano-range having the highest efficiencies. The deposition of nanoparticles in the lung can lead to chronic inflammation, epithelial injury, and further to pulmonary fibrosis. Cases of particle-induced pulmonary fibrosis, namely pneumoconiosis, are mostly occupationally influenced, and continue to be documented around the world. The tremendous growth of nanotechnology, however, has spurred fears of increased rates of pulmonary diseases, especially fibrosis. The severity of toxicological consequences warrants further examination of the effects of nanoparticles in humans, possible treatments and increased regulatory measures.

References

  1. Oberdörster G. Toxicology of Ultrafine Particles: In Vivo Studies. Philosophical Transactions of the Royal Society in London Part A 200; 358: 2719-2740.
  2. Lkhasuren O, Takahashi K, Dash-Onolt, L. Occupational Lung Diseases and the Mining Industry in Mongolia. International Journal of Environmental Occupational Health 2007; 13: 195- 201.
  3. Wang XR and Christiani DC. Occupational Lung Disease in China. International Journal of Occupational and Environmental Health 2003; 9: 320-325.
  4. Public Health Agency of Canada. Life and Breath: Respiratory Disease in Canada 2007; 32-33.
  5. Attfield MD, Wood JM, Antao VC, Pinheiro GA. Changing Patterns of Pneumoconiosis Mortality – United States, 1968- 2000. Morbidity and Mortality Weekly Report 2004; 292: 795- 796.
  6. Muller J, Huaux F, Moreau N. Respiratory Toxicity of Multi- Wall Carbon Nanotubes. Toxicology and Applied Pharmacology 2005; 207: 221-231.
  7. Donaldson K, Stone V, Borm PJ, et al. Oxidative stress and calcium signaling in the adverse effects of environmental particles (PM10). Free Radical Biology and Medicine 2003; 34:1369–1382.
  8. Duffin R, Mills NL, Donaldson, K. Nanoparticles – A Thoracic Toxicology Perspective. Yonsei Medical Journal 2007; 48: 561- 572.
  9. Gwinn MR, Vallyathan V. Nanoparticles: Health Effects – Pros and Cons. Environmental Health Perspectives 2006; 114: 1818- 1825.
  10. Oberdörster G, Oberdörster E, Oberdörster J. Nanotoxicology: An Emerging Discipline Evolving from Studies of Ultrafine Particles. Environmental Health Perspectives 2005; 113: 823 – 839.
  11. Anderson PJ, Wilson JD, Hiller FC. Respiratory Tract Deposition of Ultrafine Particles in Subjects with Obstructive or Restrictive Lung Disease. Chest 1990; 97: 1115-1120.
  12. Kreyling WG, Semmler-Behnke M, Möller W. Ultrafine Particle-Lung Interactions: Does Size Matter? Journal of Aersosol Medicine 2006; 19: 74-83.
  13. Stahlhofen W, Rudolf G, James AC. Intercomparison of experimental regional aerosol deposition data. Journal of Aerosol Medicine 1989 ; 2: 285-308.
  14. Donaldson K, Tran L, Jimenez LA, et al. Combustion-derived nanoparticles: A review of their Toxicology following Inhalation Exposure. Particle and Fibre Toxicology 2005; 2: 10.
  15. Bonner JC. Lung Fibrotic Responses to Particle Exposure. Toxicologic Pathology 2007; 35: 148-153.
  16. Donaldson K, Tran CL. Inflammation caused by Particles and Fibers. Inhalation Toxicology 2002; 14: 5-27.
  17. Mudway IS, Stenfors N, Duggan ST, et al. An in vitro and in vivo Investigation of the Effects of Diesel Exhaust on Human Airway Lining Fluid Antioxidants. Archives of Biochemistry and Biophysics 2004; 423:200–212.
  18. Baulig A, Garlatti M, Bonvallot V. Involvement of Reactive Oxygen Species in the Metabolic Pathways triggered by Diesel Exhaust Particles in Human Airway Epithelial Cells. American Journal of Physiology Lung Cellular and Molecular Physiology 2003; 285: L671-L679.
  19. Squadrito GL, Cueto R, Dellinger B, Pryor WA. Quinoid Redox Cycling as a Mechanism for Sustained Free Radical Generation by Inhaled Airborne Particulate Matter. Free Radical Biology and Medicine 2001; 31: 1132-1138.
  20. Zisman DA, Keane MP, Belperio JA, Streiter RM, Lynch JP III. Pulmonary Fibrosis. Methods in Molecular Medicine 2005; 117: 3-44.
  21. Dheda K, Booth H, Huggett JF, Johnson MA, Zumla A, Rook JA. Lung remodeling in pulmonary tuberculosis. Journal of Infectious Diseases 2005; 192: 1201-1209.
  22. Huaux F. New Developments in the Understanding of Immunology in Silicosis. Current Opinion in Allergy and Clinical Immunology 2007; 7: 168-173.
  23. Bonner JC. The Epidermal Growth Factor Receptor at the Crossroads of Airway Remodeling. American Journal of Physiology 2002; 283: L528-L530.
  24. Sime PJ, Marr RA, Gauldie D et al. Transfer of tumor necrosis factor-α to Rat Lung induces Severe Pulmonary Inflammation and patchy Interstitial Fibrogenesis with Induction of Transforming Growth Factor – β1 and myofibroblasts. American Journal of Pathology 1998; 153: 825-832.
  25. Lindroos PM, Coin PG, Badgett A, Morgan DL, Bonner JC. Alveolar Macrophages stimulated with Titanium Dioxide, chrysotile asbestos and Residual Oil Fly Ash up-regulate the PDGF Receptor-α on Lung Fibroblasts through an IL-1β- dependent Mechanism. American Journal of Respiratory Cellular and Molecular Biology 1997; 16: 283-292.
  26. Kumar V, Abbas AK, Fausto N. Tissue renewal and repair: regeneration, healing and fibrosis. In: Pathological Basis of Disease, 7th edn, pp. 87–118. 2005. Philadelphia, PA: Elsevier Saunders.
  27. Wallace WAH, Fitch PM, Simpson AJ, Howie SEM. Inflammation-associated remodeling and fibrosis in the lung – a process and an end point. Int. J. Exp. Path. 2007; 88: 103-110.
  28. Mohr LC. Hypersensitivity Pneumonitis. Currect Opinion in Pulmonary Medicine 2004; 10: 401-411.
  29. Chong S, Soo Lee K, Jin Chung M, Han J, Jung Kwon O, Sung Kim T. Pneumoconiosis: A Comparison of Imaging and Pathologic Findings. RadioGraphics 2006; 26: 59-77.
  30. Donaldson K, Tran CL, MacNee W. Deposition and effects of fine and ultrafine particles in the respiratory tract. The European Respiratory Monograph 2002; 7: 77–92.
  31. Mangum JB, Turpin EA, Antao-Menezes A, Cesta MF, Bermudez E, Bonner JC. Single-Walled Carbon Nanotube (SWCNT)-induced interstitial fibrosis in the lungs of rats is associated with increased Levels of PDGF mRNA and the formation of unique Intercellular Carbon Structures that bridge Alveolar Macrophages In Situ. Particle and Fibre Toxicology 2006; 3: 15.
  32. Lam CW, James JT, McCluskey R, Hunter RL. Pulmonary Toxicity of Single-Wall Carbon Nanotubes in Mice 7 and 90 Days after Intratracheal Instillation. Toxicological Sciences 2004; 77: 126-134.
  33. Heppleston AG. Minerals, Fibrosis, and the Lung. Environmental Health Perspectives 1991; 94: 149-168.
  34. Fujimura N. Pathology and pathophysiology of pneumoconiosis. Current Opinion in Pulmonary Medicine 2000; 6: 140-144.
  35. Hamilton RF, Thakur SA, Mayfair JK, Holian A. MARCO Mediates Silica Uptake and Toxicity in Alveolar Macrophages from C57BL/6 Mice. J Bio Chem 2006; 281: 34218-34226.
  36. Mossman BT, Churg A. Mechanisms in the Pathogenesis of Asbestosis and Silicosis. American Journal of Respiratory Critical Care Medicine 1998; 157: 1666-1680.
  37. O’Reilly KMA, Phipps RP, Thatcher TH, Graf BA, Van Kirk J, Sime PJ. Crystalline and Amorphous Silica differentially regulate the Cyclooxygenase-prostaglandin pathway in Pulmonary Fibroblasts: Implications for Pulmonary Fibrosis. American Journal of Physiology Lung and Cellular Molecular Physiology. 2005; 288: L1010-L1016.
  38. Marchiori E, Ferreira A, Müller NL. Silicoproteinosis: high- resolution CT and histologic findings. Journal of Thoracic Imaging 2001; 16: 127-129.
  39. MossmanBT,BormPJ,CastranovaV,CostaDL,DonaldsonK, Kleeberger SR. Mechanisms of action of inhaled fibers, particles and nanoparticles in lung and cardiovascular diseases. Particle and Fiber Toxicology 2007; 4: 1-10.
  40. Woodin MA, Liu Y, Neuberg D, Hauser R, Smith TJ, Christiani DC. Acute Respiratory Symptoms in Workers Exposed to Vanadium-Rich Fuel-Oil Ash. American Journal of Industrial Medicine 2000; 37: 353-363.
  41. Tran CL, Buchanan D, Cullen RT, et al. Inhalation of Poorly Soluble Particles: II. Influences of Particle Surface Area on Clearance and Inflammation. Inhalation Toxicology 2000; 12: 101-115.
  42. Hull MJ, Abraham JL. Aluminum Welding Fume-Induced Pneumoconiosis. Human Pathology 2002; 33: 819-825.
  43. Antonini JM. Health Effects of Welding. Critical Reviews in Toxicology 2003; 33: 61-103.
  44. Blanc PD, Boushey HA, Wong H, Wintermeyer SF, Bernstein MS. Cytokines in Metal Fume Fever. American Review of Respiratory Disease 1993; 147: 134-138.
  45. Taylor MD, Roberts JR, Leonard SS, Shi X, Antonini JM. Effects of Welding Fumes of Differing Composition and Solubility on free Radical Production and Acute Lung Injury and Inflammation in Rats. Toxicological Sciences 2003; 75: 181-191.
  46. McNeilly JD, Heal MR, Beverland IJ, et al. Toxicological Applied Pharmacology 2004; 196: 95-107.
  47. GhioAJ,SilbajorisR,CarsonJL,SametJM.BiologicEffectsof Oil Fly Ash. Environmental Health Perspectives 2002; 110: 89- 94.
  48. Bonner JC, Rice AB, Moomaw CR, Morgan DL. Airway Fibrosis in Rats induced by Vanadium Pentoxide. American Journal Lung Cellular and Molecular Physiology 2000; 278: L209-L216.
  49. RessNB,ChouBJ,RenneRA,etal.CarcinogenicityofInhaled Vanadium Pentoxide in F344/N Rats adn B6C3F1 Mice. Toxicological Sciences 2003; 74: 287-296.
  50. Ingram JL, Rice AB, Santos J, Van Houten B, Bonner JC. Vanadium-induced HB-EGF expression in Human Lung Fibroblasts is Oxidant Dependent and requires MAP Kinases 2003; 284: 774-782. 51. Bermudez E, Mangum JB, Wong BA, Asgharian B, Hext PM. Pulmonary Responses of Mice, Rats, and Hamsters to Subchronic Inhalation of Ultrafine Titanium Dioxide Particles. Toxicological Sciences 2004; 77: 347-357.
  51. Taubes G. Nanotechnology. An interview with Dr. Richard Smalley. ISI Essential Science Indicators Special Topics. 2002.
  52. Donaldson K, Aitken R, Tran L et al. Carbon Nanotubes: A Review of their Properties in Relation to Pulmonary Toxicology and Workplace Safety. Toxicological Sciences 2006; 92: 5-22.

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