Vol. 9 No. 2 (2006)
Research Article

Encapsulated calcium carbonate suspensions: A drug delivery vehicle sensitive to ultrasound disruption

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  • Brent Lanting,
  • Joe Barfett
DOI: https://doi.org/10.26443/mjm.v9i2.441

Published 2020-12-01

Keywords

  • alginic acid,
  • microencapsulation,
  • controlled release,
  • ultrasound

How to Cite

1.
Lanting B, Barfett J. Encapsulated calcium carbonate suspensions: A drug delivery vehicle sensitive to ultrasound disruption. McGill J Med [Internet]. 2020 Dec. 1 [cited 2025 Oct. 5];9(2). Available from: https://mjm.mcgill.ca/article/view/441
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Abstract

A calcium carbonate suspension, encapsulated within particles of calcium alginate hydrogel, is proposed as a drug delivery device susceptible to ultrasound disruption. Spheres approximately 1mm in diameter were prepared by the coaxial airflow method from mixtures of 1% sodium alginate (m/v) and each of 50%, 75% and 100% calcium carbonate (m/v) in distilled water. This product was subjected to cycles of 85 Watt ultrasound in 1 second on/off bursts via a lab sonication system until fully disintegrated, a process requiring between 8 and 20 minutes depending upon initial calcium carbonate concentrations. The spheres subjected to vortex did not demonstrate any signs of mechanical degeneration after 30 minutes. Before use as a model implant, further work is required to develop a method of drying the particles to make them impermeable to drug diffusion before the time of their disruption with ultrasound.

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