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Research Article

Vol. 9 No. 2 (2006)

Encapsulated calcium carbonate suspensions: A drug delivery vehicle sensitive to ultrasound disruption

  • Brent Lanting
  • Joe Barfett
DOI
https://doi.org/10.26443/mjm.v9i2.441
Submitted
November 1, 2020
Published
2020-12-01

Abstract

A calcium carbonate suspension, encapsulated within particles of calcium alginate hydrogel, is proposed as a drug delivery device susceptible to ultrasound disruption. Spheres approximately 1mm in diameter were prepared by the coaxial airflow method from mixtures of 1% sodium alginate (m/v) and each of 50%, 75% and 100% calcium carbonate (m/v) in distilled water. This product was subjected to cycles of 85 Watt ultrasound in 1 second on/off bursts via a lab sonication system until fully disintegrated, a process requiring between 8 and 20 minutes depending upon initial calcium carbonate concentrations. The spheres subjected to vortex did not demonstrate any signs of mechanical degeneration after 30 minutes. Before use as a model implant, further work is required to develop a method of drying the particles to make them impermeable to drug diffusion before the time of their disruption with ultrasound.

References

  1. Richard A, Margaritis A. Production and Mass Transfer Characteristics of Non-Newtonian Biopolymers for Biomedical
  2. Applications. Critical Reviews in Biotechnology 22(4): 355- 374; 2002.
  3. Chemical Market Reporter, Drug Delivery Market Poised for Five Years of Strong Growth. Schnell Publishing, New York, 258(23); 2000.
  4. Sershen S, West J. Implantable Polymeric Systems for Modulated Drug Delivery. Advanced Drug Delivery Reviews 54:1225-1235; 2002.
  5. Kost J, Wolfrum J, Langer R. Magnetically Enhanced Insulin Release in Diabetic Rats. Journal of Biomedical Materials Research 21: 1367-1373; 1987.
  6. Kwok C, Mourad PD, Crum LA, Ratner BD. Self-Assembled Molecular Structures as Ultrasonically-Responsive Barrier
  7. Membranes for Pulsatile Drug Delivery. Journal of Biomedical Materials Research 57(2): 151-164; 2001.
  8. Dinarvand R, D'Emanuele A. The Use of Thermoresponsive Hydrogels for On-Off Release of Molecules. Journal of Controlled Release 36: 221-227; 1995.
  9. Fiszman GL, Karara, AL, Finocchiaro, LME, Glikin GC. A Laboratory Device for Microencapsulation of Genetically
  10. Engineered Cells into Alginate Beads. Electronic Journal of Biotechnology 5(3); 2002.
  11. Mitri FG, Fellah ZEA, Closset E, Trompette P, Chapelon JY. Determination of Object Resonances by Vibro-Acoustography
  12. and their Associated Modes. Ultrasonics 42(1-9): 537-543; 2004.
  13. Yang H, Wright JR. Calcium Alginate. In: Kuhtreiber WM, Lanza RP, Chick WL. Cell Encapsulation Technology and
  14. Therapeutics. Berlin, Germany: Birkhauser Publishing, 1999.
  15. Millman JS. Diffusivity Characteristics of Globular Proteins in Calcium Alginate Immobilization Matrices. Faculty of Graduate Studies, University of Western Ontario, London, ON, 1992.
  16. Dulieu C, Poncelet D, Neufeld R. Encapsulation and Immobilization Techniques. In: Goosen MFA, editor.
  17. Fundamentals of Animal Cell Encapsulation. Anne Arbor, MI: CRC Press, 1993.

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