Wolff J. The Law of Bone Remodelling. (1892) translated by Maquet P and Furlong R. New York, NY: Springer-Verlag; 1986.
Lanyon LE. The physiological basis of training the skeleton. Equine Veterinary Journal Suppl 9: 8-13; 1993.
Rubin CT, McLeod KJ. Promotion of bony ingrowth by frequency-specific, low-amplitude mechanical strain. Clinical Orthopaedics 298: 165-174; 1994.
Hamanishi C, Kawaabata T, Yoshii T, Tanaka S. Bone mineral density changes in distracted callus stimulated by pulsed direct electrical current. Clinical Orthopaedics 312: 247-252; 1995.
Cohen B, Millett PJ, Laskey M, Mist B, Rushton N. Effect of exercise training programme on bone mineral density in novice college rowers. The British Journal of Sports Medicine (in press); 1995.
Rodan GA, Martin TJ. Role of osteoblasts in hormonal control of bone resorption - a hypothesis. Calcified Tissue International 33(4): 349-351; 1981.
Parfitt AM. The coupling of bone formation to resorption: a critical analysis of the concept and of its relevance to the pathogenesis of osteoporosis. Metabolic Bone Disease and Related Research 4: 1-6; 1982.
Manolagas SC, Jilka RL. Bone marrow, cytokines, and bone remodeling. New England Journal of Medicine 322(5): 305-311; 1995.
Rodan GA. Introduction to bone biology. Bone 13: s3-6; 1992.
Tenenbaum HC. Cellular origins and theories of differentiation. Hall BK, ed. Bone: Volume I. The Osteocyte. New Jersey: The Telford Press, 41-69; 1990.
Urist MR, Delange RJ, Finerman GAM. Bone cell differentiation and growth factors. Science 220: 680- 686; 1983.
Forell EB, Straw RC. Bone morphogenetic proteins and bone-derived growth factors. Veterinary Comparative Orthopaedics and Traumatology 6: 166-171; 1993.
Strutzman JJ, Petrovic AG. Bone cell histogenesis: the skeletoblast as a stem cell for preosteoblasts and for secondary-type prechondroblasts. Dixon AD, Sarnat BG, eds. Factors and Mechanisms Influencing Bone Growth. New York, NY: Alan R Liss Inc., 29-45; 1982.
Whyte MP. Fibrodysplasia ossificans progressiva. Favus MJ, ed. Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism. New York, NY: Lippincott, 393-395; 1993.
Holtrop ME. Light and electron microscopic structure of bone-forming cells. Hall BK, ed. Bone: Volume I. The Osteocyte. New Jersey: The Telford Press, 1-39; 1990.
Scherft JP, Heersche JNM. Accumulation of collagen-containing vacuoles in osteoblasts after administration of colchicine. Cell and Tissue Research 157: 355-365; 1975.
Steln GS, Lian JB, Owen TA. Relationship of cell growth to the regulation of tissue-specific gene expression during osteoblast differentiation. FASEB Journal 4: 3111-3123; 1990.
Rodan GA, Rodan SB. Expression of the osteoblast phenotype. Peck WA, ed. Bone Mineral Research. Vol. 2. Amsterdam : Elsevier, 244-262; 1983.
Millett PJ. Investigations into the activity of osteoblasts in vitro and in vivo. Dissertation. University of Cambridge; 1994.
Skojdt M, Russell G. Bone cell biology and the regulation of bone turnover. Gowen M, ed. Cytokines and Bone Metabolism. Florida: CRC Press, 1-70; 1992.
Fang MA, Hahn TJ. Effects of interleukin-6 on cellular function in UMR 106-01 osteoblast-like cells. Journal of Bone and Mineral Research 6: 133-139; 1991.
Price PA, Baukol SA. 1,25 dihydroxyvitamin D3 increases the synthesis of the vitamin K-dependent protein by osteosarcoma cells. Journal of Biological Chemistry 255: 11660-11663; 1980.
Beresford J, Gallagher JA, Poser JW, Russell RGG. Production of osteocalcin by human bone cells in vitro. Effects of 1,25-(OH)2 D3, 24,25-(OH)2 D3, parathyroid hormone, and glucocorticoids. Metabolic Bone
Disease and Related Research 5: 229-234; 1984.
Owen TA, Aronow MS, Barone LM, Bettencourt B, Stein GS, Lian JB. Pleiotropic effects of vitamin D on osteoblast gene expression are related to the proliferative and differentiated state of the bone cell phenotype: dependency upon basal levels of gene expression, duration of exposure, and bone matrix competency in normal rat osteoblast cultures. Endocrinology 128: 1496-1504; 1991.
Bonewald LF, Kester MB, Schwartz Z, et al. Effects of combining transforming growth factor and 1,25 dihydroxyvitamin D3 on differentiation of human osteosarcoma (MG-63). Journal of Biological Chemistry 267: 8943-8949; 1992.
McSheehy PMJ, Chambers TJ. Osteoblast-like cells in the presence of parathyroid hormone release soluble factor that stimulates osteoclastic bone resorption. Endocrinology 119: 1654-1659; 1986.
Risteli L. Assays of collagen metabolism. Kirjapaino Libris Oy, Helsinki: Orion Diagnostica; 1993. 30. Risteli L, Risteli J. Biochemical markers of bone metabolism. Annals of Medicine 25: 385-393; 1993.
Whyte MP. Osteogenesis imperfecta. Favus MJ, ed. Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism. New York, NY: Lippincott, 346-349; 1993.
Van der Rest M, Garrone R. Collagen family of proteins. FASEB Journal 5: 2814-2823; 1991.
Harris H. The human alkaline phosphatase, what we know and what we don't know. Clinica Chimica Acta 186: 133-136; 1989.
Stigbrand T. Present status and future trends of human alkaline phosphatases. Human Alkaline Phosphatases. New York, NY: Alan R. Liss, 3-14; 1984.
Cole DE, Cohen MM. Mutations affecting bone forming cells. Hall BK, ed. Bone: Volume I. The Osteoblast and the Osteocyte. New Jersey: The Telford Press, 442-452; 1990.
McComb RB, Bowers GN Jr, Posen S. Alkaline Phosphatase. New York, NY: Plenum Press; 1979.
Whyte MP. Hypophosphatasia. Favus MJ, ed. Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism. New York, NY: Lippincott, 288-290; 1993.
Farley JR, Hall SL, Tanner MA, Wergedal JE. Specific activity of skeletal alkaline phosphatase in human osteoblast-line cells regulated by phosphate, phosphate esters, and phosphate analogs and release of alkaline phosphatase activity inversely regulated by calcium. Journal of Bone and Mineral Research 9: 497-508; 1994.
Fedde KN. Human osteosarcoma cells spontaneously release matrix-vesicle-like structures with the capacity to mineralize. Bone and Mineral 17: 145-151; 1992.
Rodan SB, Imai Y, Thiede MA, et al. Characterization of a human osteosarcoma cell line (Saos-2) with osteoblastic properties. Cancer Research 47: 4961-4966; 1987.
Leung KS, Fung KP, Sher AHL, Li CK, Lee KM. Plasma specific alkaline phosphatase as an indicator of osteoblastic activity. Journal of Bone and Joint Surgery (Br) 75-B: 288-292; 1993.
Poser JW, Esch FS, Ling NC, Price PA. Isolation and sequence of the vitamin K-dependent protein from human bone. Journal of Biological Chemistry 255: 8685-8691; 1980.
Brozovic M. Oral anticoagulants, vitamin K, and prothrombin complex factors. British Journal of Haematology 32: 9; 1976.
Price PA. Vitamin K-dependent formation of bone Gla protein (osteocalcin) and its function. Vitamins and Hormones 42: 65-108; 1985.
Malone JD, Teitelbaum GL, Griffin GL, Senior RM, Kahn AJ. Recruitment of osteoclast precursors by purified bone matrix constituents. Journal of Cell Biology 92: 227-238; 1982.
Cole DE, Hanley DA. Osteocalcin. In Hall BK, ed. Bone: Volume III. The Bone Matrix. New Jersey: The Telford Press, 239-294; 1990.
Skojdt H, Gallagher JA, Beresford JN, Couch M, Poser JW, Russell RGG. Vitamin D metabolites regulate osteocalcin synthesis and proliferation of human bone cells in vitro. Journal of Endocrinology 105: 391-396; 1985.
Yoon K, Rutledge SJC, Buenaga F, Rodan GA. Characterization of the rat osteocalcin gene: stimulation of promoter activity by 1,25 dihydroxyvitamin D3. Biochemistry 27: 8521-8526; 1988.
Robey P, Boskey A. Bone matrix proteins at a glance. Feldman D, ed. Osteoporosis (in press); 1995.
Reichel H, Koeffler P, Norman A. The role of the vitamin D endocrine system in health and disease. New England Journal of Medicine 320: 980-991; 1989.
Kelly PJ. Genetic factors in bone turnover. Journal of Clinical Endocrinology and Metabolism 72: 808- 814; 1991.
Morrison NA, Oi JC, Tokita A, et al. Prediction of bone density from vitamin D receptor alleles. Nature 367: 284-287; 1994.
Franceschi RT, Romano PR, Park KY. Regulation of type I collagen synthesis by 1,25 dihydroxyvitamin D3 in human osteosarcoma cells. Journal of Biological Chemistry 263: 18938-18945; 1988.
Lemann J. Urinary excretion of calcium, magnesium, and phosphorus. Favus MJ, ed. Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism. New York, NY: Lippincott, 50-54; 1993.
Klein GL. Nutritional rickets and osteomalacia. Favus MJ, ed. Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism. New York, NY: Lippincott, 264-267; 1993.
Hershman JM. Endocrine Pathophysiology. Philadelphia, PA: Lea and Febiger, 266-267; 1988.
Lane NE, Thompson JM, Haupt D, Kinney JH. Intermittent therapy with parathyroid hormone increases trabecular bone mass but not connectivity in osteopenic rats. Transactions of the 41st Annual Meeting of the Orthopaedic Research Society 20(1): 234; 1995.
Paterson JD, Shea M, Miller P, Mitlak D, Neer R, Hayes WC. Parathyroid hormone (PTH1-84) increases bone morphologic and biomechanical properties in estrogen-deficient rats. Transactions of the 41st Annual Meeting of the Orthopaedic Research Society 20(1): 280; 1995.
Wilson JD and Foster DW, eds. Williams Textbook of Endocrinology. London: WB Saunders Company; 1992.
Kassem M, Brixen L, Mosekilde L, Eriksen EF. Human marrow stromal osteoblast-like cells do not show reduced responsiveness to in vitro stimulation with growth hormone in patients with postmenopausal osteoporosis. Calcified Tissue International 54: 1-6; 1994.
Clifford CJ, Scotchford CA, Klein CPAT, Downes S. Potential of hydroxyapatite and related ceramics as vehicles for controlled drug delivery. Transactions of the European Orthopaedic Research Society 4: P45; 1994.
Murray D, Rushton N. The effect of strain on bone cell prostaglandin E2 release: a new experimental method. Calcified Tissue International 47: 35-39; 1990.
Kawaguchi H, Pilbeam CC, Harrison JR, Raisz LG. The role of prostaglandins in the regulation of bone metabolism. Clinical Orthopaedics 313: 36-46; 1995.
Gowen M. Cytokines and skeletal disorders. Baxter A, Ross R, eds. Cytokine Interactions and their Control. London: John Wiley and Sons, 125-137; 1991.
Hauschka PV, Mavrakos AE, Iafrati MD, Doleman SE, Klagsbrun M. Growth factors in bone matrix. Journal of Biological Chemistry 261: 12665-12674; 1986.
Mohan S, Baylink DJ. Bone growth factors. Clinical Orthopaedics. 262:30-48;1990.
Kirker-Head CA, Gerhart T, Henning G, et al. Long-term healing of large mid-femoral segmental defects in sheep using recombinant human bone morphogenetic protein-2 and inactive decalcified ovine bone matrix. Transactions of the 40th Annual Orthopaedic Research Society 19(2): 505; 1994.
Nielson HM, Andreassen TT, Ledet T, Oxlund H. Local injection of TGF-ß increases the strength of tibial fractures in the rat. Acta Orthopaedica Scandinavia 65: 37-41; 1994.