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Research Article

Vol. 11 No. 1 (2008)

Protein expression of MEF2C during the critical period for visual development in vervet monkeys

  • Daniel M Bernad
  • Pascal E Lachance
  • Avijit Chaudhuri
DOI
https://doi.org/10.26443/mjm.v11i1.355
Submitted
October 25, 2020
Published
2020-12-01

Abstract

During the early development of the visual cortex, there is a critical period when neuronal connections are highly sensitive to changes in visual input. Deprivation of visual stimuli during the critical period elicits robust anatomical and physiological rearrangements in the monkey visual cortex and serves as an excellent model for activity-dependent neuroplasticity. DNA microarray experiments were previously performed in our lab to analyze gene expression patterns in area V1 of vervet monkeys subjected to monocular deprivation (MD). An interesting candidate identified in its screen was myocyte enhancer-binding factor 2C (MEF2C), a transcription factor linked to neuronal survival. Consistent with the microarray data, we show that there is a qualitative increase in MEF2C protein expression in area V1 of infant as compared to adult vervet monkeys. Our results suggest that the regulation of neuronal survival is one of the molecular mechanisms underlying the critical period for visual cortical neuroplasticity.

References

  1. Hubel DH, Wiesel TN. Receptive fields, binocular interaction and functional architecture in the cat’s visual cortex. J. Physiol. (London) 1962 Jan;160:106-54.
  2. Katz L. What’s critical for the critical period of visual cortex? Cell. 1999 Dec 23;99(7):673-6.
  3. Antonini A, Stryker MP Rapid remodeling of axonal arbors in the visual cortex. Science. 1993 Jun 18;260(5115):1819-21.
  4. Kandel ER, Schwartz JH, Jessel TM. Central Visual Processing. In: Wurtz RH, Kandel ER,editors. Principles of Neural Science. New York: McGraw Hill; 2000. p. 521-545.
  5. Gordon JA. Cellular mechanisms of visual cortical plasticity: a game of cat and mouse. Learn Mem. 1997 Sep-Oct;4(3):245-61.
  6. Toldi J, Feher O, Wolff J. Neuronal plasticity induced by neonatal monocular (and binocular) enucleation. Prog Neurobiol. 1996 Feb;48(3):191-218.
  7. Lachance PE, Chaudhuri A. Microarray analysis of developmental plasticity in monkey primary visual cortex.J Neurochem. 2004 Mar;88(6):1455-69.
  8. Bi W, Drake CJ, Schwarz JJ. The transcription factor MEF2C-null mouse exhibits complex vascular malformations and reduced cardiac expression of angiopoietin 1 and VEGF. Dev Biol. 1999 Jul 15;211(2):255-67.
  9. Lin Q, Lu J, Yanagisawa H, et al. Requirement of the MADS- box transcription factor MEF2C for vascular development. Development. 1998 Nov;125(22):4565-74.
  10. Lachance P, Chaudhuri A. Functional genomics of primate visual cortical neuroplasticity. Society for neuroscience 31st Annual meeting.2001; San Diego, Ca.
  11. Soderling T CaM-Kinases: modulators of synaptic plasticity. Curr Opin Neurobiol. 2000 Jun;10(3):375-80.
  12. Mellstrom B, Naranjo JR Mechanisms of calcium-dependent transcription. Curr Opin Neurobiol. 2001 Jun;11(3):312-9.
  13. Kogan CS, Zangenehpour S, Chaudhuri A. Developmental profiles of SMI-32 immunoreactivity in monkey striate cortex. Brain Res Dev Brain Res. 2000 Jan 3;119(1):85-95.
  14. Chaudhuri A. Neuronal activity mapping with inducible transcription factors. Neuroreport. 1997 Nov 10;8(16):v-ix.
  15. Lalonde J, Lachance PE, Chaudhuri A. Monocular enucleation induces nuclear localization of calcium/calmodulin-dependent protein kinase IV in cortical interneurons of adult monkey area V1. J Neurosci. 2004 Jan 14;24(2):554-64.
  16. Crowley JC, Katz LC. Early development of ocular dominance columns. Science. 2000 Nov 17;290(5495):1321-4.
  17. Leysen I, Van der Gucht, Eysel UT, Huybrechts, Vandesande F, Arckens L. Time-dependent changes in the expression of the MEF2 transcription factor family during topographic map reorganization in mammalian visual cortex.Eur J Neurosci. 2004 Aug;20(3):769-80.
  18. Okamoto S, Li Z, Ju C, Scholzke M, Mathews E, Cui J, Salvensen G, Bossy-Wetzel E, Lipton S (2002) Dominant- interfering forms of MEF2C generated by caspase cleavage contribute to NMDA-induced neural apoptosis. PNAS 99:3974- 3979.

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