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Research Article

Vol. 18 No. 1 (2020)

The role of probiotics in inhibition mechanism of methicillin-resistant staphylococcus aureus

DOI
https://doi.org/10.26443/mjm.v18i1.156
Submitted
March 8, 2020
Published
2020-08-30

Abstract

ABSTRACT

Methicillin-resistant Staphylococcus aureus (MRSA) is a hospital-acquired pathogen with high prevalence across the globe. It raises a serious health concern due to its resistance to antibiotic agents, in particular, β-lactam, carbapenem, and penem. This pathogen causes various medical conditions, namely endocarditis, osteomyelitis, pneumonia, toxic shock syndrome (TSS), and food poisoning. Strains of lactic acid bacteria (LAB) such as Lactobacillus sp. and Bifidobacterium sp. inhibit pathogenic bacteria through competition for nutrients and adhesion sites, production of antimicrobial substances, and enhancement of immune system. The present hypothesis describes that these probiotics prevent the growth of MRSA by producing inhibitory agents like bacteriocin, lactic acid, acetic acid, propionic acid, hydrogen peroxide, and the intestinal pH reduction. Given an increasing resistance to antibiotics and its adverse effects, the use of other alternatives seems necessary. These beneficial bacteria and their metabolites which are available in the market as tablets, capsules, and powders can widely establish control over the growth of MRSA.

References

  1. David MZ, Daum RS. Treatment of Staphylococcus aureus Infections. Curr Top Microbiol Immunol. 2017;409:325-83.
  2. DeLeo FR, Chambers HF. Reemergence of antibiotic-resistant Staphylococcus aureus in the genomics era: J Clin Invest. 2009 Sep 1;119(9):2464-74. doi:10.1172/JCI38226.
  3. Askari E, Soleymani F, Arianpoor A, Tabatabai SM, Amini A, NaderiNasab M. Epidemiology of mecA-Methicillin Resistant Staphylococcus aureus (MRSA) in Iran: A Systematic Review and Meta-analysis: Iran J Basic Med Sci. 2012 Sep-Oct;15(5):1010-9.
  4. Opławski M, Dziobek K, Adwent I, Dąbruś D, Grabarek B, Zmarzły N, et al. Expression profile of endoglin in different grades of endometrial cancer. Current pharmaceutical biotechnology. 2018;19(12):990-5.
  5. Spagnolo A, Orlando P, Panatto D, Amicizia D, Perdelli F, Cristina M. Staphylococcus aureus with reduced susceptibility to vancomycin in healthcare settings: J Prev Med Hyg. 2014 Dec;55(4):137-44.
  6. Martins A, Cunha Mde L. Methicillin resistance in Staphylococcus aureus and coagulase-negative staphylococci: epidemiological and molecular aspects. Microbiol Immunol. 2007;51(9):787-95.
  7. Pillai MM, Latha R, Sarkar G. Detection of Methicillin Resistance in Staphylococcus Aureus by Polymerase Chain Reaction and Conventional Methods: A Comparative Study: J Lab Physicians. 2012 Jul-Dec;4(2):83-8. doi:10.4103/0974-2727.105587.
  8. Alvarez-Olmos MI, Oberhelman RA. Probiotic agents and infectious diseases: a modern perspective on a traditional therapy. Clin Infect Dis. 2001;32(11):1567-76.
  9. Holzapfel WH, Haberer P, Snel J, Schillinger U, Huis in't Veld JH. Overview of gut flora and probiotics. Int J Food Microbiol. 1998;41(2):85-101.
  10. Gardiner GE, O'Sullivan E, Kelly J, Auty MAE, Fitzgerald GF, Collins JK, et al. Comparative Survival Rates of Human-Derived Probiotic Lactobacillus paracasei and L. salivarius Strains during Heat Treatment and Spray Drying: Appl Environ Microbiol. 2000 Jun;66(6):2605-12.
  11. Rolfe RD. The role of probiotic cultures in the control of gastrointestinal health. J Nutr. 2000;130(2S Suppl).
  12. Tetili F, Bendali F, Perrier J, Sadoun D. Anti-Staphylococcal Enterotoxinogenesis of Lactococcus lactis in Algerian Raw Milk Cheese: Food Technol Biotechnol. 2017 Dec;55(4):511-8. doi:10.17113/ftb.55.04.17.5105.
  13. Klaenhammer TR. Bacteriocins of lactic acid bacteria. Biochimie. 1988;70(3):337-49.
  14. Lewus CB, Kaiser A, Montville TJ. Inhibition of food-borne bacterial pathogens by bacteriocins from lactic acid bacteria isolated from meat: Appl Environ Microbiol. 1991 Jun;57(6):1683-8.
  15. Kalchayanand, N., M. Hanlin, and B. Ray, Sublethal injury makes Gram‐negative and resistant Gram‐positive bacteria sensitive to the bacteriocins, pediocin AcH and nisin. Letters in Applied Microbiology, 1992. 15(6): p. 239-243.
  16. Eloe-Fadrosh EA, Rasko DA. The human microbiome: from symbiosis to pathogenesis. Annu Rev Med. 2013;64:145-63.
  17. Conway PL, Gorbach SL, Goldin BR. Survival of lactic acid bacteria in the human stomach and adhesion to intestinal cells. J Dairy Sci. 1987;70(1):1-12.
  18. Fuller R. Probiotics in human medicine. Gut. 1991;32(4):439-42.
  19. Kaila M, Isolauri E, Soppi E, Virtanen E, Laine S, Arvilommi H. Enhancement of the circulating antibody secreting cell response in human diarrhea by a human Lactobacillus strain. Pediatr Res. 1992;32(2):141-4.
  20. Belkaid Y, Hand TW. Role of the microbiota in immunity and inflammation. Cell. 2014;157(1):121-41.
  21. Czerucka D, Rampal P. Experimental effects of Saccharomyces boulardii on diarrheal pathogens. Microbes Infect. 2002;4(7):733-9.
  22. Schillinger U, Lücke FK. Antibacterial activity of Lactobacillus sake isolated from meat. Applied and environmental microbiology. 1989;55(8):1901-6.
  23. Merlino J, Watson J, Rose B, Beard-Pegler M, Gottlieb T, Bradbury R, et al. Detection and expression of methicillin/oxacillin resistance in multidrug-resistant and non-multidrug-resistant Staphylococcus aureus in Central Sydney, Australia. Journal of Antimicrobial chemotherapy. 2002;49(5):793-801.
  24. McDougal LK, Thornsberry C. New recommendations for disk diffusion antimicrobial susceptibility tests for methicillin-resistant (heteroresistant) staphylococci. Journal of clinical microbiology. 1984;19(4):482-8.
  25. Asgharzadeh M, Kafil HS, Roudsary AA, Hanifi GR. Tuberculosis transmission in Northwest of Iran: using MIRU-VNTR, ETR-VNTR and IS6110-RFLP methods. Infection, Genetics and Evolution. 2011;11(1):124-31.
  26. Toledo-Arana A, Valle J, Solano C, Arrizubieta MaJ, Cucarella C, Lamata M, et al. The enterococcal surface protein, Esp, is involved in Enterococcus faecalis biofilm formation. Applied and environmental microbiology. 2001;67(10):4538-45.
  27. Morin NJ, Gong Z, Li X-F. Reverse Transcription-Multiplex PCR Assay for Simultaneous Detection of Escherichia coli O157:H7, Vibrio cholerae O1, and Salmonella Typhi. Clinical Chemistry. 2004;50(11):2037-44.
  28. Schellenberg J, Smoragiewicz W, Karska-Wysocki B. A rapid method combining immunofluorescence and flow cytometry for improved understanding of competitive interactions between lactic acid bacteria (LAB) and methicillin-resistant S. aureus (MRSA) in mixed culture. Journal of microbiological methods. 2006;65(1):1-9.
  29. Lazarenko L, Babenko L, Sichel LS, Pidgorskyi V, Mokrozub V, Voronkova O, et al. Antagonistic action of lactobacilli and bifidobacteria in relation to Staphylococcus aureus and their influence on the immune response in cases of intravaginal staphylococcosis in mice. Probiotics and antimicrobial proteins. 2012;4(2):78-89.
  30. Glück U, Gebbers J-O. Ingested probiotics reduce nasal colonization with pathogenic bacteria (Staphylococcus aureus, Streptococcus pneumoniae, and β-hemolytic streptococci). The American journal of clinical nutrition. 2003;77(2):517-20.
  31. Maqueda M, Sánchez-Hidalgo M, Fernández M, Montalbán-López M, Valdivia E, Martínez-Bueno M. Genetic features of circular bacteriocins produced by Gram-positive bacteria. FEMS microbiology reviews. 2008;32(1):2-22.
  32. Cotter PD, Hill C, Ross RP. Bacteriocins: developing innate immunity for food. Nature Reviews Microbiology. 2005;3(10):777-88.
  33. Karska-Wysocki B, Bazo M, Smoragiewicz W. Antibacterial activity of Lactobacillus acidophilus and Lactobacillus casei against methicillin-resistant Staphylococcus aureus (MRSA). Microbiological research. 2010;165(8):674-86.
  34. Bauer G. Lactobacilli-mediated control of vaginal cancer through specific reactive oxygen species interaction. Medical hypotheses. 2001;57(2):252-7.
  35. Queck SY, Jameson-Lee M, Villaruz AE, Bach T-HL, Khan BA, Sturdevant DE, et al. RNAIII-independent target gene control by the agr quorum-sensing system: insight into the evolution of virulence regulation in Staphylococcus aureus. Molecular cell. 2008;32(1):150-8.
  36. Fahad HJ, Radeef HM. Capability of Lactobacillus acidophilus supernatant to inhibit production of lipase from methicillin-resistant Staphylococcus aureus. J Univ Anbar Pure Sci. 2011;5:1-5.
  37. Gan BS, Kim J, Reid G, Cadieux P, Howard JC. Lactobacillus fermentum RC-14 inhibits Staphylococcus aureus infection of surgical implants in rats. Journal of infectious Diseases. 2002;185(9):1369-72.
  38. Fan Z, Cao L, He Y, Hu J, Di Z, Wu Y, et al. Ctriporin, a New Anti-Methicillin-Resistant Staphylococcus aureus Peptide from the Venom of the Scorpion Chaerilus tricostatus: Antimicrob Agents Chemother. 2011 Nov;55(11):5220-9. doi:10.1128/AAC.00369-11.

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